It's been almost 25 years since Amazon sold its first book online, and even as many have come to depend on online retailers, e-commerce still only represents 14% of retail purchases globally. But that's changing -- eMarketer reported last year that online purchases are expected to grow by double digits annually and exceed 22% of all retail spending by 2023. But that forecast was made before the coronavirus pandemic affected how we live, work, and shop. There are already signs that e-commerce adoption has accelerated in recent months. In order to capitalize on this growing trend, let's look outside the U.S. to three regional specialists -- JD.Com Inc (NASDAQ: JD) in China, MercadoLibre (NASDAQ: MELI) in Latin America, and Sea Limited (NYSE: SE) in Southeast Asia -- and see why investors are excited about this international trio. But first, let's look at some statistics to understand the regional market opportunity where these companies operate. A large and growing regional opportunity China is by far the most developed e-commerce market, with 37% of all retail sales completed online, but there's still plenty of opportunity with three times the internet users of the U.S. and a strong growth rate of 27%. Metrics United States China Southeast Asia Latin America Population 330 million 1.4 billion 662 million 638 million Internet users 285 million 903 million 416 million 362 million 2019 E-commerce as % of retail sales 11.8% (Q4 only) 37% 2.4% 4.2% 2019 E-commerce growth 14% 27% 31% 21% Data from eMarketer, U.S. Census Bureau, Statista, Worldometers, and MercadoLibre company report. Table by author. Southeast Asia boasts more than double the internet users of the U.S., but still has only a tiny 2.4% of purchases made online. Latin America has almost double the population of the U.S., and as mobile devices become more accessible in the region, e-commerce sales will grow beyond the low sub-5% rate it has today. The opportunity in these regions is incredible, but so are the leading e-commerce players that operate in them. Let's take a closer look at three of them. JD.com: China's largest direct retailer JD.com is the second-largest e-commerce operator in China behind Alibaba, but it's the top online direct retailer in the region. It has built a robust network of over 730 warehouses across the region, which has been a competitive advantage during the pandemic, enabling it to quickly ramp back to full operational capacity after being shut down for the Chinese new year. Image source: Getty Images. JD.com's growth has been tremendous. Over the span of 2015 to 2019, it grew the top line at a 34% compound annual growth rate. Its grocery and pharmacy businesses are now larger than any brick-and-mortar competitor. Its award-winning fulfillment services provide customers with a reliable online experience that has helped drive its annual active customer count to 387 million, a 25% increase from the prior year. With 15 trillion expected to be spent online in China by 2023, this is one e-commerce player you should consider for your portfolio. MercadoLibre: Latin America's e-commerce leader and more Not only has MercadoLibre sold over $14.3 billion worth of merchandise on its website the last twelve months, it also processed an astounding $30.9 billion on its payments system, MercadoPago. Payment processing has grown to 42% of the top line last quarter and helped by a triple-digit growth rate year over year. E-commerce revenues posted strong growth as well, coming in at a 38% rate based on U.S. dollars, but is even more impressive (up 70%) when you look at it based on local currency. As internet and mobile usage increase in the coming years, MercadoLibre is well positioned with its complete ecosystem of payments, fulfillment centers, and delivery network to help fuel the growth of online activity in the region. You could do well by becoming a shareholder in this high-quality operator. Sea Limited: Southeast Asia's triple threat Not only does Sea Limited have a growing e-commerce business and a payments platform, it's into online gaming too. Its digital entertainment division, Garena, accounted for over 50% of its revenue last quarter on the back of a 113% growth over the previous year. Not to be outdone, its e-commerce business, Shopee, grew 84% in its most recent quarter year over year. The company doesn't disclose its payments revenue as it's rolled up under the Shopee segment, but it did have more than $1 billion in total transactions from over 10 million SeaMoney mobile wallet users in Q1 2020. Sea Limited has a wide moat and a ton of momentum in a region where e-commerce is just getting started. Investors with a long-term view should consider owning this multifaceted growth company. Are international stocks for you? International stocks don't come risk-free. Lack of financial transparency, political and currency instability in emerging economies, and less visibility to hungry competitors are just a few of the risks. But these three solid operators have proven growth models in huge markets with plenty of opportunity to grow in the years ahead. Investors would be smart to start with a few shares in one or all of these regional specialists today and build their positions over time. Shareholders will certainly benefit as more of the 2.7 billion people in these regions come to depend on e-commerce as part of their daily lives. 10 stocks we like better than MercadoLibreWhen investing geniuses David and Tom Gardner have a stock tip, it can pay to listen. After all, the newsletter they have run for over a decade, Motley Fool Stock Advisor, has tripled the market.* David and Tom just revealed what they believe are the ten best stocks for investors to buy right now... and MercadoLibre wasn't one of them! That's right -- they think these 10 stocks are even better buys. See the 10 stocks *Stock Advisor returns as of April 16, 2020 John Mackey, CEO of Whole Foods Market, an Amazon subsidiary, is a member of The Motley Fool's board of directors. Brian Withers owns shares of Amazon, JD.com, MercadoLibre, and Sea Limited. The Motley Fool owns shares of and recommends Alibaba Group Holding Ltd., Amazon, JD.com, and MercadoLibre. The Motley Fool recommends Sea Limited and recommends the following options: short January 2022 $1940 calls on Amazon and long January 2022 $1920 calls on Amazon. The Motley Fool has a disclosure policy.Source